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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of isotype switching to IgE isotypes
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Accession:GO:0048293 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes.
Synonyms:exact_synonym: regulation of class switch recombination to IgE isotypes;   regulation of class switching to IgE isotypes;   regulation of isotype switch recombination to IgE isotypes

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negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr15:81,997,659...82,022,059
Ensembl chr15:81,998,545...82,009,946 		JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17137798) Ensembl
MGI		 PMID:17137798 GO_REF:0000107 NCBI chr23:44,737,432...44,783,409
Ensembl chr23:44,737,422...44,775,657 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) BHF-UCL PMID:12496423 MGI:3763508 NCBI chr25:55,714,291...55,998,009
Ensembl chr25:55,974,691...55,997,374 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in ISO (MGI:3777853|PMID:12023368) BHF-UCL PMID:12023368 MGI:3777853 NCBI chr 1:6,890,751...6,900,370 JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14988498) TreeGrafter
MGI		 PMID:14988498 GO_REF:0000118 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr11:53,005,378...53,020,899
Ensembl chr11:53,006,145...53,021,203 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16925
    immune system process 2492
      production of molecular mediator of immune response 246
        immunoglobulin production 116
          regulation of immunoglobulin production 86
            regulation of isotype switching 39
              regulation of isotype switching to IgE isotypes 7
                negative regulation of isotype switching to IgE isotypes 3
                positive regulation of isotype switching to IgE isotypes + 4
                regulation of interleukin-4-dependent isotype switching to IgE isotypes + 1
Path 2
Term Annotations click to browse term
  biological_process 16925
    metabolic process 10515
      organic substance metabolic process 10067
        organic cyclic compound metabolic process 5671
          nucleobase-containing compound metabolic process 5211
            nucleic acid metabolic process 4699
              DNA metabolic process 906
                DNA recombination 329
                  somatic cell DNA recombination 76
                    somatic diversification of immune receptors via germline recombination within a single locus 76
                      somatic recombination of immunoglobulin gene segments 64
                        somatic recombination of immunoglobulin genes involved in immune response 56
                          isotype switching 56
                            isotype switching to IgE isotypes 7
                              regulation of isotype switching to IgE isotypes 7
                                negative regulation of isotype switching to IgE isotypes 3
                                positive regulation of isotype switching to IgE isotypes + 4
                                regulation of interleukin-4-dependent isotype switching to IgE isotypes + 1
paths to the root